![]() In the early morning period (6 am to 10 am), baseline BP was 155/98 +/- 11/7 mm Hg and the RPP was 12,084 +/- 1752 mm Hg.beats.minute. Patients enrolled in the trial (n = 35) had a mean age of 55 +/- 7 years, 24-hour mean BP of 148/91 +/- 11/7 mm Hg, heart rate (HR) of 76 +/- 10 beats/minute, and a RPP of 11,230 +/- 1717 mm Hg.beats.minute). Patients were included if they were untreated, had hypertension based on both clinic (140 to 179/90 to 109 mm Hg) and ABP recordings (>135/85 mm Hg while awake), and were 18 to 65 years of age. ![]() ![]() amlodipine (5 mg titrated to 10 mg for clinic BP >140/90 mm Hg) on the 24-hour and early morning hemodynamic parameters, we performed a double-blind crossover trial that included 8 weeks of active treatment, 4 weeks of placebo washout, and 8 weeks of active crossover treatment using 24-hour ambulatory blood pressure (ABP) measurements. To evaluate the clinical effects of metoprolol succinate extended release (ER) tablets (100 mg titrated to 200 mg for clinic BP >140/90 mm Hg) vs. Ambulatory monitoring of the blood pressure (BP) and heart rate allows for the assessment of the 24-hour rate-pressure product (RPP), a close correlate of myocardial oxygen demand, both in the untreated state and while on antihypertensive therapy.
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